longevity cosmetics

Signs of oxidative stress on the skin

Written by EMA TAILLANDIER on March 30, 2026, updated on April 20, 2026

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Summary

The effects of oxidative stress on the skin become apparent gradually. Collagen and elastin fibers, damaged by oxidation, lose their structural integrity—the skin loses its suppleness, resilience, and firmness. The skin barrier becomes weakened.

The most common signs of oxidative stress on the face:

• dull complexion and lack of radiance

• premature wrinkles and loss of firmness

• uneven texture, less uniform skin tone

• increased skin fragility, sensitivity to environmental stressors

• loss of density and elasticity

These signs aren’t just related to age. They reflect a biological condition. They indicate that the skin is no longer able to effectively neutralize what it is exposed to.

Oxidative stress and inflammation are also closely linked. An excess of free radicals can trigger an inflammatory response which, even when silent, disrupts cellular repair mechanisms and accelerates tissue breakdown. The two phenomena feed off each other, creating a cycle that the skin alone cannot break.

What plants figured out before we did

In the plant world, oxidative stress is a constant reality. Exposed to sunlight, climatic variations, and environmental stressors, plants have developed highly sophisticated molecular defense systems.

Among the molecules naturally produced by plants to combat oxidative stress:

• polyphenols, powerful free-radical scavengers

• flavonoids, which have antioxidant and anti-inflammatory properties

• carotenoids, which protect cellular structures from oxidation

• tannins and phenolic acids, found particularly in peonies and white lilies

It is this understanding of living organisms that inspires the scientific approach of Laboratoires Botanique Avancée. Species such as the peony, white lily, and iris, cultivated at Domaine Baulieu a preserved Mediterranean environment, have developed remarkable adaptive capabilities. These properties are studied and harnessed through plant biotechnology for their potential in protecting and regenerating the skin.

Preserve, rather than correct

Research on longevity , particularly the work of Prof. Jean-Marc Lemaître atINSERM, highlights the critical role of oxidative stress in cellular aging. Preserving the skin’s biological functions over time—its ability to regenerate, repair itself, and defend itself—is a challenge that goes beyond mere appearance.

It is with this in mind that LBA develops its skincare products: not to correct the signs of aging that have already set in, but to preserve the skin’s natural functions. To support its antioxidant defenses. To strengthen its resilience. To act proactively, consistently, and precisely.

Viewed in this way, skincare becomes as much a biological process as it is an aesthetic one.

Q&A

What is oxidative stress?

Oxidative stress refers to an imbalance between the production of free radicals—unstable molecules produced by metabolism and the environment—and the body’s ability to neutralize them. When it exceeds the body’s natural defenses, it damages cellular structures and accelerates aging.

What causes oxidative stress?

The main causes are UV exposure, air pollution, chronic stress, smoking, and a diet low in antioxidants. These factors increase the production of free radicals beyond what the body’s natural defenses can handle.

What are the signs of oxidative stress on the skin?

Dull complexion, premature wrinkles, loss of radiance, uneven texture, and delicate skin. These signs point to a biological imbalance and are not solely related to age.

What is the link between oxidative stress and inflammation?

An excess of free radicals can trigger chronic, low-grade skin inflammation, which in turn impairs repair mechanisms and accelerates tissue breakdown. The two phenomena feed into each other.

How does diet affect oxidative stress?

Certain nutrients—such as vitamin C, vitamin E, polyphenols, and beta-carotene—support the body’s antioxidant defenses. Conversely, excessive sugar and ultra-processed foods contribute to biological imbalances.

Why are plants effective against oxidative stress?

Constantly exposed to adverse conditions, plants have developed highly sophisticated molecular defense mechanisms. These molecules—polyphenols, flavonoids, and antioxidants—serve as a major source of inspiration for botanical cosmetics.

What is the link between oxidative stress and skin aging?

Oxidative stress is one of the key biological mechanisms underlying cellular aging. It damages collagen and elastin fibers, disrupts the skin barrier, and reduces the skin’s ability to regenerate over time.

How is L.B.A. addressing this challenge?

By developing skincare products designed to support the skin’s natural defense and regeneration mechanisms—rather than simply correcting issues after the fact. This approach relies on plant-based biotechnological active ingredients, evaluated using advanced biological models in collaboration with Prof. Jean-Marc Lemaître atINSERM.